Freckles Minimizing Natural Cosmetic Ingredients Alpha Arbutin Powder CAS 84380 01 8

Cosmetic Ingredient Freckles Minimizing Alpha Arbutin Powder a-Arbutin CAS 84380 01 8

Alpha-arbutin:

CAS No.: 84380-01-8

Molecular Formula: C12H16O7

Molecular Weight: 272.26

Specification: ≥99.5%

Solubility: Soluble in cold water (151g/l at 20degree), and can be easily incorporated into cosmetic formulation either warm(<70degree)or cold. ALPHA-ARBUTIN is compatible with UV filters and ethanol at concentrations of up to 50%.

α-arbutin:α-arbutin:(Alpha Arbutin) is a new type of hydroquinone glucoside with an α-glucosyl bond.

Arbutin is commercially used as a skin-whitening agent in cosmetic industry. It works by competitive inhibition of the enzyme, tyrosinase, a key enzyme in the synthesis of melanin.

Depending on the spatial structure of the glycosidic linkage between glucose and hydroquinone, arbutin forms two epimers: Alpha Arbutin and Beta arbutin.

Alpha Arbutin is enzymatically synthesized from hydroquinone and saccharides through transglycosylation reaction. Various carbohydrate-active enzymes such as α-amylase, α-glucosidase, transglucosidase, sucrose phosphorylase, and dextransucrase have been employed to synthesize Alpha Arbutin. It is one of the most advanced skin lightening ingredients on the market.

Recent research showed that Alpha-Arbutin has a 10-fold stronger inhibitory effect on the activity of tyrosinase from human malignant melanoma cells than that of Beta-Arbutin. The α-glucosidic bond found in Alpha-Arbutin offers higher stability than the β form found in the related Beta-Arbutin. Moreover, Alpha-Arbutin hardly inhibited cell growth at 1 mmol/L, while Beta-Arbutin inhibit it significantly at the same concentration. It is, therefore, considered that Alpha-Arbutin is an effective and safe ingredient for cosmetics. Alpha arbutin is very expensive. That is the one downside.

Skin Whitening Mechanism of α-Arbutin
There are two functional groups on α -arbutin: 
Anhydroglucose unit- That has hydrophilicity 
Phenolic group- Repress the activity of tyrosinase
Therefore, α -Arbutin has the functions of WHITENING AND
MOISTURING