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Silymarin / Silybin Natural Dietary Supplements CAS 22888 70 6 Milk Thistle Plant Extract Preventing Liver Disorder

Silymarin / Silybin Natural Dietary Supplements CAS 22888 70 6 Milk Thistle Plant Extract Preventing Liver Disorder

  • Silymarin / Silybin Natural Dietary Supplements CAS 22888 70 6 Milk Thistle Plant Extract Preventing Liver Disorder
  • Silymarin / Silybin Natural Dietary Supplements CAS 22888 70 6 Milk Thistle Plant Extract Preventing Liver Disorder
Silymarin / Silybin Natural Dietary Supplements CAS 22888 70 6 Milk Thistle Plant Extract Preventing Liver Disorder
Product Details:
Place of Origin: China
Brand Name: Phytocare
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: 25kg/carbon drum; Tare: 2.8kg; diameter 50cm, height 40cm. 1kg/bag.
Payment Terms: L/C, D/A, D/P, T/T,PAYPAL
Supply Ability: 1000kg/month
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Detailed Product Description
Silybin: 90%, 95%, 98% Source: Milk Thistle Seed
Appearance: Off White / Slight Yellow Powder Solvent: Ethanol / Water
Name: Milk Thistle Extract Latin Name: Silybum Marianum(Linne) Gaertner
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Silymarin & Silybin CAS No. 22888 70 6 of Milk Thistle Plant Extract Preventing Liver Disorder

 

 

 

Plant Source of Milk Thistle Extract:

Milk thistle is commonly found growing wild in a variety of settings, including roadsides. The Latin name is Silybum marianum. The seeds of the dried flower are used. The active ingredient in the plant is a flavonoid called silymarin, an antioxidant said to protect liver cells from toxins. Silymarin apparently promotes liver cell protein synthesis and decreases the oxidation of glutathione. The plant's flowers and seeds have been used for more than 2,000 years to treat disorders of the liver and gallbladder.

 

 

Basic Info:

Product Name Milk Thistle Extract
Latin Name Silybum marianum(Linne) Gaertner
Part Used Seed
Solvent Used Ethanol & Water
Active Ingredient Silybin
CAS No. 22888-70-6
Molecular Weight 482.44
Molecular Formula C25H22O10
Specification 90%, 95%, 98%
Test Method HPLC
Appearance Off white or slight yellow powder
Packing size 25kg/drum, 1kg/bag
Shelf Life 3 years
Country of Origin China


Silibinin (INN), also known as silybin (both from Silybum, the generic name of the plant from which it is extracted), is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin, and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. The mixture exhibits a number of pharmacological effects, particularly in the liver.

 

Chemical Structurer of Silybin A and Silybin B:

Silymarin / Silybin Natural Dietary Supplements CAS 22888 70 6 Milk Thistle Plant Extract Preventing Liver Disorder 0

 

Silymarin / Silybin Natural Dietary Supplements CAS 22888 70 6 Milk Thistle Plant Extract Preventing Liver Disorder 1

 

 

Certificate of Analysis of Silybin 90%:

Product Milk Thistle Extract Ingredient Silybin
Latin Name Silybum marianum(Linne) Gaertner
Batch no. P0130-180505 Batch Qty 500kgs
MFG Date 2018.05.03 Report Date 2018.05.25
Analysis:
Items Specification Result
Assay (HPLC) ≥90% 91.47%
Charaters Similar to white or slight yellow powder, no smell Complies

Identification

(1) Ferric Chloride Reaction

(2) UV Absorption

(3) Infra-red Absorption

Brown precipitate

Max 288nm/Min252nm

Same as the standard

Complies

Complies

Complies

Heavy Metals ≤20ppm Complies
Cd <5.0ppm Complies
Hg <0.2ppm Complies
Pb <0.1ppm Complies
As <2.0ppm Complies
Loss on Drying (2h130℃) ≤3.0% 2.23%
Sulphated Ash ≤0.20% 0.10%
Melting Point 181-185℃ Complies

Organic Solvents Residue

Ethanol

≤0.5% 0.29%
Microbiological Control
Total Plate Count 1000cfu/g 25cfu/g
Yeasts&Molds 100cfu/g 10cfu/g
Salmonella Negative Complies
E.Coli Negative Complies
Pseudomonas aeruginsa Negative Complies
Staphylococcus aeruginsa Negative Complies
Conclusion QUALIFIED
Packing 25kg/drum; Total: 20 drums.
Storage Keep in cool dry place, avoid sun and heat.
Shelf Life 3 years from original packing condition.

 

Applications:

Liver protection

Silibinin is available as drug (Legalon SIL (Madaus) (D, CH, A) and Silimarit (Bionorica), a Silymarin product) in some EU countries and used in the treatment of toxic liver damage (e.g. IV treatment in case of death cap poisoning); as adjunctive therapy in chronic hepatitis and cirrhosis.

 

Silibinin is under investigation to see whether it may have a role in cancer treatment (e.g. due to its inhibition of STAT3 signalling).

 

Silibinin also has a number of potential mechanisms that could benefit the skin. These include chemoprotective effects from environmental toxins, anti-inflammatory effects, protection from UV induced photocarcinogenesis, protection from sunburn, protection from UVB-induced epidermal hyperplasia, and DNA repair for UV induced DNA damage (double strand breaks).

 

 

Contact Details
Shenyang Phytocare Ingredients Co.,Ltd

Contact Person: Ms. Chen

Tel: +8613704033823

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Tel:86--13704033823
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